Tuesday, August 25, 2020

Terrorism Essay

Numerous individuals see war as the main answer for coo associate psychological oppression, yet there are others that oppose this idea. In this article I will examine and contrasting the o choice of war with elective choices that can supplant it. The initial two alternatives both included the military. Choice one included utilizing nit class to find and bomb psychological oppressor preparing camps, and alternative two was to dominate or destabilize governments that are thoughtful to the fear monger by sending in prepared troop s. In contrasting this with war saw that these alternatives are very similar.By shelling the fear monger camps this would make them fight back, and the final product would be a war. Choice TV&'0 would likewise wind up as a war on the grounds that after your soldiers have attacked the tally rye the nation would retaliate making you need to prepare more soldiers to send into fight. Choices 3 and 4 are centered around internal center significance not engaging in any issues abroad and concentrating on why fear mongers would assault you? These two pop activities are vastly improved in light of the fact that there would be no war except if the fear based oppressors assaulted first.Wit h no war there would be no dead warriors which would thusly support the economy since t here would be more specialists. Choices 5 and 6 include outreach, implying that as opposed to doing battle we wow old contact and discover what the fear mongers need. This effort would likewise include e creating associations with various networks in our own nation and somewhere else. B cover inning these associations with different nations would assist us with framing more grounded bonds with to hers. Accordingly we would turn out to be to a lesser extent an objective for fear based oppressors.

Saturday, August 22, 2020

The Industrial Revolution for the Disabled :: Essays Papers

The Industrial Revolution for the Disabled In this new time of Internet and the World Wide Web, everything is open. In the event that you required cutting-edge news, research, or amusement; simply go on the web. Ordinary individuals underestimate this decision, perhaps by obliviousness or by ineptitude, however a little, ever-developing populace don't have these decisions. The impaired have conquered numerous pregitouses and were once viewed as intellectually and truly hindered. However, as of late, various associations have perceived the requirement for the handicapped to accomplish extreme web availability. Obviously, extreme won't be accomplished for quite a while, however some accessiblility is superior to none. The Americans with Disabilities Act has just concocted availability prerequisites that the Federal Government has embraced. (Pertinence of... 2000) Aol has changed it's configuration because of a claim by the National Federation for the visually impaired. (Relevance of... 2000) Not just are open parts changing their sites, yet numerous private areas are also (Applicability of... 2000) To guarantee people with handicaps have full and equivalent satisfaction in the offices they give when the arrangement of such access is quantifiable. (Materialness of... 2000) Assistive Technology Assistive Technology is any gadget, bit of hardware, of programming that is utilized to assist an individual with an incapacity or weakness, arrive at full useful limit. A few instances of cutting edge assistive innovation incorporate voice acknowledgment frameworks, voice combination, enormous print show, braille decorating, and elective PC input gadgets. (University of Iowa) Some insights on the broad worry of designers for open sites include:50 million individuals in the U.S. have a useful impediment. 15% of those can't utilize a PC without some type of assistive innovation and about 8% of the individuals who utilize the Web have handicaps. (McKeefy 1998) As research shows the web is carrying a universe of data to clients with inabilities, however antagonistically, it is hard for vision impeded individuals to get to a mixed media rich website. (McKeefy 1998) New hardware for the sight-debilitated are currently accessible, however one may think it is just accessible to individuals with cash. As indicated by Greg Meise, President of Lenexa (a Kansas based affiliate), 'Declining innovation costs currently have made these items accessible to a more extensive crowd. Moderateness has changed the market.' (McKeefy 1998) The costs of these uncommon innovations have dropped and disabled clients have a choice of blended advancements. (McKeefy 1998) Mindfulness The ADA (Americans with Disabilities Act) has set up prerequisites for the web to make sites open for individuals with handicaps.

Saturday, August 1, 2020

Winter Days

Winter Days Now that winter is approaching and snow is officially falling, students need to take a different approach to getting to classes and final exams at Illinois. With the cold and harsh weather, one needs to find different ways to dress and alternate ways to reach the buildings necessary during the day. Dressing semi-light, taking buses and cars, and planning trips ahead of time are  the best ways students can handle winter weather on campus. Courtesy: sheerwx.blogspot.com First, when dealing with cold and snowy weather in Campaign-Urbana, I encourage students to work out a method of automotive transportation. The campus has a generous busing department that  provides stops to nearly all the corners of the university. The buses are well heated and allow you to get from point A to B in the frigid weather with very little outdoor trekking. Also, if you are fortunate to have a car on campus, parking is readily available as long as you know where to park ahead of time. With these resources, a student has choices in getting around during the coldest times of the year. Courtesy: web.mta.info In the cold weather, one also needs to dress for the occasion. Here, the idea is to dress in a way that is against normal logic. I recommend the light layering of clothing for the colder seasons on campus because it allows for easy movement, a lack of sweating (which makes you cold later), and simply less to carry around. Wearing lighter clothing such as a windbreaker over a sweater will allow you to stay warm without paying for it later. Courtesy: blog.cdc.com Finally, in the arctic-like weather at  the end of the semester, a student at Illinois should really have his or her  daily route planned. This is not just so one can get to classes on time, but so that one has a trip criterion that  favors main streets that  are plowed or the shortest trip when less outdoor time is key to a good day. In other words, the shorter and cleaner the trip, the better. And so, as a transfer student I have found a well-dressed and well-planned trip in a vehicle is the best way to commute across the Illinois campus in the cold months. Jacob Class of 2018 I am a transfer student studying Engineering Physics in the College of Engineering. I started with the Illinois Engineering Pathways program through the College of DuPage. I am from Naperville, Illinois.

Friday, May 22, 2020

THe Windover Bog Site, an Archaic Pond Cemetery

Windover Bog (and sometimes known as Windover Pond) was a pond cemetery for hunter-gatherers, people who lived hunting game and gathering vegetable material between about 8120-6990 years ago. The burials were staked down in the soft mud of the pond, and over the years at least 168 people were buried there, men, women, and children. Today that pond is a peat bog, and preservation in peat bogs can be quite astonishing. While the burials at Windover were not as well preserved as those of European  bog bodies, 91 of the individuals buried contained bits of brain matter still intact enough for scientists to retrieve DNA. Perishable Artifacts of Middle Archaic Most interesting, however, is the recovery of 87 samples of weaving, basketry, woodworking and clothing, providing us more information on the perishable artifacts of Middle Archaic people in the American southeast than archaeologists ever dreamed possible. Four kinds of close twining, one kind of open twining, and one type of plaiting can be seen in the mats, bags, and basketry recovered from the site. Clothing woven by the inhabitants of Windover Bog on looms included hoods and burial shrouds, as well as some fitted clothing and many rectangular or squarish clothing articles. While the perishable fiber plaits from Windover Bog are not the oldest found in the Americas, the textiles are the oldest woven materials found to date, and together they broaden our understanding of what the Archaic lifestyle was truly like. DNA and Windover Burials Although scientists believed they had retrieved DNA from the fairly intact brain matter recovered from some of the human burials, subsequent research has shown that the mtDNA lineages reported are absent in all other prehistoric and contemporary Native American populations studied to date. Further attempts to retrieve more DNA have failed, and an amplification study has shown that there is no analyzable DNA left in the Windover burials. In 2011, researchers (Stojanowski et al) studied dental variation characteristics on teeth from Windover Pond (and Buckeye Knoll in Texas) that at least three of the individuals buried there had projections on incisors called talon cusps or an enlarged tuberculum dentale. Talon cusps are a rare trait globally  but are more common in the western hemisphere than elsewhere. Those at Windover Pond and Buckeye Knoll are the oldest found in the Americas to date, and the second oldest in the world (the oldest is Gobero, Niger, at 9,500 cal BP). Sources This article is a part of the About.com Guide to American Archaic Period, and part of the Dictionary of Archaeology. Adovasio JM, Andrews RL, Hyland DC, and Illingworth JS. 2001. Perishable industries from the Windover Bog: An unexpected window into the Florida archaic. North American Archaeologist 22(1):1-90. Kemp BM, Monroe C, and Smith DG. 2006. Repeat silica extraction: a simple technique for the removal of PCR inhibitors from DNA extracts. Journal of Archaeological Science 33(12):1680-1689. Moore CR, and Schmidt CW. 2009. Paleoindian And Early Archaic Organic Technologies: A Review And Analysis. North American Archaeologist 30(1):57-86. Rothschild BM, and Woods RJ. 1993. Possible implications of paleopathology for early archaic migrations: Calcium pyrophosphate deposition disease. Journal of Paleopathology 5(1):5-15. Stojanowski CM, Johnson KM, Doran GH, and Ricklis RA. 2011. Talon cusp from two archaic period cemeteries in North America: Implications for comparative evolutionary morphology. American Journal of Physical Anthropology 144(3):411-420. Tomczak PD, and Powell JF. 2003. Postmarital Residence Patterns in the Windover Population: Sex-Based Dental Variation as an Indicator of Patrilocality. American Antiquity 68(1):93-108. Tuross N, Fogel ML, Newsom L, and Doran GH. 1994. Subsistence in the Florida Archaic: The stable-isotope and archaeobotanical evidence from the Windover site. American Antiquity 59(2):288-303.

Sunday, May 10, 2020

Essay Procrastination of Revenge in William Shakespeares...

Procrastination of Revenge in William Shakespeares Hamlet In the play â€Å"Hamlet† by William Shakespeare, the protagonist Hamlet, the Prince of Denmark, is deceived by many of his former allies, including his mother, Gertrude, and his lover, Ophelia. Perhaps the most deceptive of these former allies is Hamlet’s uncle, Claudius. Not only does Claudius kill Hamlet’s father, the King, but he also proceeds to marry Hamlet’s mother, Gertrude, and to steal the crown from Hamlet, the rightful heir to his father. In Act III, scene III of â€Å"Hamlet,† Hamlet accidentally comes upon Claudius while he is alone and in prayer. Hamlet draws his sword and contemplates murdering Claudius. However, Hamlet neglects to perform this action. The†¦show more content†¦Ã¢â‚¬Å"Now might I do it pat, now ‘a is a-praying, And now I’ll do’t.† (III, iii, 73-74) However, Hamlet’s intellect provides him with a ready excuse to delay his revenge against Claudius. Hamlet does not believe that killing a man in prayer constitutes an unfair deed. Rather, Hamlet reasons that, since Claudius has purged his soul through prayer, he would go to heaven. â€Å"And so ‘a goes to heaven; And so am I revenged.† (III, iii, 75) Hamlet’s father, contrastingly, had not prepared his soul for death. He suffered purgatory as a ghost. Hamlet, unsatisfied with performing an act of corporeal justice, would prefer for his revenge to have eternal consequences. He wants to seek his revenge when Claudius’ sole lies in a state of unpreparedness. Hamlet puts away his sword while contemplating this future occasion. â€Å"Up, sword; and know thou a more horrid hent: when he is drunk asleep, or in his rage, Or in th’ incestuous pleasure of his bed; At game, a-swearing, or about some act That has no relish of salvation in’t;† (III, iii, 88-92) This procrastination shows Hamlet’s capabilities for intellectual reason, even in a situation involving extreme emotions. However, this decision presents Hamlet’s final opportunity to seek substantial revenge against Claudius. In this scene, Hamlet shows reasoning worthy of admiration. Although Claudius’ prayer may evoke sympathy from anShow MoreRelated Soliloquy and Revenge in Hamlet Essay662 Words   |  3 PagesSoliloquy and Revenge in Hamlet      Ã‚  Ã‚   The soliloquy is a literary device that is employed to unconsciously reveal an actors thoughts to the audience. In William Shakespeares, Hamlet, Hamlets soliloquy in Act II, ii, (576-634) depicts his arrival at a state of vengeful behaviour through an internal process. Hamlet moves through states of depression and procrastination as he is caught up in the aftermath of the murder of his father and the marriage of his mother to his uncle. The soliloquyRead MoreCause and Effect Hamlet Essay902 Words   |  4 PagesCause and Effect Hamlet Essay William Shakespeare, arguably the greatest language in the English language and England’s national poet, has written numerous histories, tragedies, comedies and poems. Throughout his plays, his use of dramatic irony, immaculate word choice and wording, and his vast imagination has made him a successful playwright even in his time. Shakespeare’s scripts for his theatrical company, needed to pertain to the needs and fascinations of the Elizabethan audience. It is safeRead MoreHamlet, Prince of Denmark825 Words   |  4 PagesHamlet, Prince of Denmark By William Shakespeare Submitted by: Tariq Khan Dated: Monday, 24th September, 2012 Hamlet as a Tragedy by William Shakespeare 1.1. Brief Introduction to Tragedy: Greek and English: Elizabethan tragedy is traced back to Greek tragedy, since Greeks are said to have pioneered the Western knowledge, be it Science, Arts, or Humanities—not necessarily Technology. The rich contribution of Greek dramatists like Sophocles, Euripides, Aeschylus and AristophanesRead MoreAn Examination Of Impulse, Procrastination And Its Consequences1860 Words   |  8 PagesExamination of Impulse, Procrastination and its Consequences in William Shakespeare’s Hamlet American playwright Maxwell Anderson once stated in his essay, Off Broadway, that, â€Å"the story of a play must be a conflict, and specifically, a conflict between the forces of good and evil within a single person.† The most memorable characters in literature have dealt with struggles both internal and external, in terms of either heroic or cowardly means. In William Shakespeare’s play Hamlet, the title characterRead MoreHamlet : A Tragic Hero995 Words   |  4 PagesHamlet: A Tragic Hero William Shakespeare is known through the ages as a brilliant playwright. He has written several comedies and tragedies that people have loved through decades. Shakespeare’s plays have been interpreted in many different ways and have been debated on which interpretation is correct. Some of these included even the basis of the character’s persona. In the Shakespearean tragedy Hamlet, the main protagonist, Prince Hamlet, is fated by the ghost of his late father that, becauseRead MoreHow Hamlets Mental State Changes in the Soliloquies in Hamlet by Shakespeare745 Words   |  3 PagesHamlets Mental State Changes in the Soliloquies in Hamlet by Shakespeare In William Shakespeare’s â€Å"Hamlet† there are four major soliloquies that reflect the character of Hamlet. In this paper I will be analyzing and discussing how these four soliloquies reflect changes in Hamlet’s mental state; his changing attitudes toward life and the other characters in the play, particularly the women; and his reflection on the task of revenge that has been assigned to him. These four soliloquiesRead MoreWhy Does Hamlet Procrastinate?999 Words   |  4 PagesWhy Does Hamlet Procrastinate? In a situation where ones mother turns her back on you and your emotional state of mind after your father had just died and expects you to put up with the fact she has married your fathers brother within 3 months of his death†¦from a drama perspective you would be expected by a paying audience that you would go all straight away guns blazing in order to exact swift brutal revenge on the people who have, in a metaphoric sense, dropped a whole load faeces on you and yourRead MoreHamlet Cause and Effect Essay1716 Words   |  7 Pagesand surprise the audience as much as possible (Roff).† Hamlet is a dramatic production written by William Shakespeare. â€Å"The play, set in the Kingdom of Denmark, recounts how Prince Hamlet exacts revenge on his uncle Claudius for murdering the old King Hamlet, Claudiuss own brother and Prince Hamlets father, and then succeeding to the throne and marrying Gertrude, the King Hamlets widow and mother of Prince Hamlet (Hamlet†).† Sh akespeare’s main objective was to impress his Elizabethan audienceRead MoreThe Struggle with Procrastination in Hamlet by William Shakespeare1002 Words   |  5 PagesThe Struggle with Procrastination in Hamlet by William Shakespeare In William Shakespeare’s tragic play Hamlet, the main character, Hamlet, struggles with procrastination throughout the play. As Samuel Taylor Coleridge said, No brilliant intellect can be considered valuable if one withdraws from action. It is this tragic flaw of inaction that eventually brings about Hamlet’s downfall. In the beginning of the play, Hamlet is given explicit instructions by the ghost toRead MoreAnalysis Of Hamlets Character Development Throughout His Soliloquies1370 Words   |  6 PagesSoliloquies are common in Shakespeare’s plays as it allows characters in the play to speak directly to the audience and address their true thoughts and feelings. In Hamlet written by William Shakespeare, Hamlet has several soliloquies that help to form a deeper, more developed character. These soliloquies give the reader the opportunity to understand how Hamlet is struggling with his father’s death and his mother’s new marriage. They also allow the au dience to grasp the trouble Hamlet is having while making

Wednesday, May 6, 2020

Patient Falls Free Essays

Preventing Patient Falls in Inpatient Hospital Settings Introduction For the most part, hospitals are places where one comes for healing and it is place where our clients should feel safe and away from harm. Nurses have an important role as a patient advocate and are to provide all clients with safe, compassionate, and quality care at all times. Nonetheless, the hospital can also be a dangerous place for inpatients. We will write a custom essay sample on Patient Falls or any similar topic only for you Order Now It is a foreign environment to clients and there may be alterations in their medical condition in regards to their physical and/or mental status. With this said, there is a need to improve upon how we care for our clients, especially those who are at most risk for various incidents. Background Certain facilities have dedicated efforts such as research and quality improvement teams to prevent incidents, yet patient falls still make up the largest category of reported incidents in hospitals (The Joint Commission, 2007). As nurses, we see fall prevention programs such as using fall risk assessment tools to determine how many our patients are at risk for falls. In the inpatient setting, nurses also implement bed alarms and encourage â€Å"fall risk† clients to use the call light especially while getting up and out of bed. Although these tools ensure some security for our clients, it is not enough as it does not fully protect our patient population. This problem is significant to nursing as it compromises the safety and well-being of our clients, affects the length of stay, and also affects finances for both the patient and the hospital. So the question is: how can we promote safer hospital stays and prevent inpatient falls? Method This exploratory study used a qualitative research design that was conducted in one acute, medical adult unit (32 beds) in a Michigan medical center. The clinical nurses who currently work in the study unit were recruited for interviews. † (Tzeng, 2008) These participants were asked for their input regarding how and why patient falls occur in the hospital setting according to their perspective, and to think of ways to implement new regulations and ways to prevent inpatient falls. (Tzeng, 2008) It would be ideal to create a fall prevention team that includes current staff who are directly involved n the care of clients. This team would include physicians, former or current staff nurses, assisting personnel, and other healthcare members since they all spend time at the patients’ bedside, and they may have insight into areas of improvement that others may not see. An interdisciplinary effort would be an overall better approach when dealing with precautions that would affect the facility’s policy and procedure changed in the facility. (Hughes, 2007) All of the members input about healthcare improvement may be highly constructive and would greatly benefit safety goals. The Joint Commission emphasizes that a better physical design of facilities may also lead to improved healthcare outcomes such as fewer patient falls. (Joint Commission, 2007) Results â€Å"The primary root causes of fatal falls as reported by healthcare organizations involved inadequate staff communication, incomplete orientation and training, incomplete patient assessment and reassessment, environmental issues, incomplete care planning, unavailable or delayed care provision, and inadequate organizational culture of safety. (Joint Commission, 2007) If a client is high-fall-risk, implementing continuous observation by bringing in a sitter for the patient would be best. If there are patients that are demented or confused, it may be ideal to inform and educate the family to visit and care for them as much as possible so that it provides the client with a familiar environment. If there are bed alarms set for certain patients, maybe it is best to group these patients closer to nurses st ation so the responsible nurse to could hear the alarms better and react faster. Other findings include communicating changes in the patients’ behavior and conditions to oncoming nurses during shift change. Educating the family is always beneficial, so that they know about details such as non-slip socks, the importance of keeping the side rails up, and using the call light in concerns. Considering all over-the-counter and prescription drugs the client is taking is important, as well as considering the physical environment and thoroughly assessing and re-assessing clients for any physical and mental changes. Ensuring that the client’s room and restroom are clean, dry, and free of clutter should also be a concern. For nurses especially, we should not also rely on housekeeping or the aides. If we could go out our way, just for a few minutes, this may just be enough sometimes to keep our patients out of harm’s way. Ethical Considerations People with autonomy have the freedom to choose between multitudes of options. (Burkhardt Nathaniel, 2008) Autonomy is the ability to freely choose amongst a variety of options that would have certain effects on a person’s life. Most of the clients that seek healthcare are independent in caring for themselves or formerly independent in self-care. At times, nurses encounter clients who seem to be stubborn or not enthused with the idea that now at a certain time of their life, they are not able to do things completely by themselves. Their autonomy has now been compromised by medical or other conditions they have. Nurses encounter problems with certain people who do not call for help or have healthcare personnel assist them when they really are at risk for falls and other injuries. If a problem such as this arises, clients should be made aware that nurses and aides are always willing to help even if it is just a trip to the restroom. Clients should be re-assured that they are not being bothersome and ask for assistance at any time during their patient stay. This is how nurses should promote beneficence and ensure trust amongst our patient population. Conclusion Ensuring client safety should be the main concern for nurses and healthcare professionals. Although the Joint Commission has addressed problems with client falls, there is always room for improvement. Nurses should be known as bedside leaders because out of the rest of the interdisciplinary team, we know our patients the best and they are our priority. References Burkhardt, M. A. , Nathaniel, A. K. (2008). Ethics and Issues in Contemporary Nursing (3rd ed. , pp. 452-453). Clifton Park, NY: Delmar Cengage Learning. Hart-Hughes, S. , Quigley, P. , Palacios, P. , Bulat, T. , Scott, S. (2007 ). An Interdisciplinary Approach to Reducing Fall Risks and Falls. Journal of Rehabilitation,  70(4), 46-51. Retrieved February 9, 2012, from CINAHL Plus with Full Text. Joint Commission, The. (2007). National Patient Safety Goals — Facts about the 2007 National Patient Safety Goals. Retrieved February 7, 2012, from http://www. jointcommission. org/PatientSafety/NationalPatientSafetyGoals/07_npsg_facts. htm Tzeng, H. , Yin, C. (2008, June). Nurses’ Solutions to Prevent Inpatient FallsHospital Settings [Electronic version]. Nursing Economics,  26(3), 179-187. Retrieved February 9, 2012, from CINAHL Plus with Full Text. How to cite Patient Falls, Essay examples

Thursday, April 30, 2020

The Time Machine by HG Well Essay Example For Students

The Time Machine by HG Well Essay The Time Machine by HG Wells was the first Science Fiction book ever to be published and it is as groundbreaking now as it was when it was first published in 1898. The Novel starts in Victorian London. The narrator is visiting a friend who is holding a diner party with the other upper class intellectual professionals of the time. The narrators friend is only known as the Time Traveller. We know that he lives in Richmond, he is an inventor and he is in the company of the some of the most important people in society. HG Wells builds up suspense and mystery around the Time Traveller by not revealing his name. We will write a custom essay on The Time Machine by HG Well specifically for you for only $16.38 $13.9/page Order now The people who come to the time travellers dinner party are all very important upper class members of society. They are the Mayor, the Medical man (Doctor), the Psychologist, the very young man, Filby and the Narrator. We do not know about the background of Filby or the Narrator but as they contribute quite often in the conversation we can tell they are intelligent and are obviously from the same social class. On the first evening that the time traveller invites his friends around for dinner, he shows them all an instrument that he says he will send forward in time. He makes sure that all of his guests see that he is not playing a trick on them and the instrument disappears with no logical explanation to any of the visitors. Some of them are sceptical and refuse to believe it is real. The Time Traveller offers to show them the time machine he is building to prove he is not a fake and they follow him into his laboratory. When the guests leave the party they are still baffled by the trick and so the Time Traveller tells them to return next Thursday so that he can prove himself. When the narrator returns to the Time Travellers house in Richmond the Time Traveller is not there, in the drawing room a few of the other visitors are waiting for the Time Traveller to arrive. When they finally decide to start eating dinner without him, the Time Traveller bursts into the room covered in blood and dirty. He tells them the story of how he travelled into the future. The Time Traveller tells of how he finished his work on the Time Machine and set off on his journey on the morning of the day of the second diner party. He had travelled thousands of years into the future and found himself in a green and pleasant London inhabited by a very strange race of creatures called Eloi. He makes friends with the Eloi and they show him the building where they communally live. He believes they are the descendants of the human race. He is impressed with the way in which they live together in such a peaceful society although he is struck by the fact the creatures are extremely childlike. The Eloi all sleep in the same area and they all eat together. There are none of the problems that exist in HG Wells Victorian London such as poverty or crime, There is no sign of struggle, neither social nor economical. He thinks that over the generations as the Eloi developed their way of life and became more and more idle, they lost the need for strength, so that is why they are so unintelligent and weak, Strength is the outcome of need. This is the Time Travellers first revelation. HG Wells uses the Elois society as a way of criticising the political theory of communism, saying that even if the society is made up of equals that do not need to labour to be members of the society, it wont work because people will evolve into weak and stupid creatures. .uf3f833ba6ebfbd97b8e82cf6aaa24211 , .uf3f833ba6ebfbd97b8e82cf6aaa24211 .postImageUrl , .uf3f833ba6ebfbd97b8e82cf6aaa24211 .centered-text-area { min-height: 80px; position: relative; } .uf3f833ba6ebfbd97b8e82cf6aaa24211 , .uf3f833ba6ebfbd97b8e82cf6aaa24211:hover , .uf3f833ba6ebfbd97b8e82cf6aaa24211:visited , .uf3f833ba6ebfbd97b8e82cf6aaa24211:active { border:0!important; } .uf3f833ba6ebfbd97b8e82cf6aaa24211 .clearfix:after { content: ""; display: table; clear: both; } .uf3f833ba6ebfbd97b8e82cf6aaa24211 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .uf3f833ba6ebfbd97b8e82cf6aaa24211:active , .uf3f833ba6ebfbd97b8e82cf6aaa24211:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .uf3f833ba6ebfbd97b8e82cf6aaa24211 .centered-text-area { width: 100%; position: relative ; } .uf3f833ba6ebfbd97b8e82cf6aaa24211 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .uf3f833ba6ebfbd97b8e82cf6aaa24211 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .uf3f833ba6ebfbd97b8e82cf6aaa24211 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .uf3f833ba6ebfbd97b8e82cf6aaa24211:hover .ctaButton { background-color: #34495E!important; } .uf3f833ba6ebfbd97b8e82cf6aaa24211 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .uf3f833ba6ebfbd97b8e82cf6aaa24211 .uf3f833ba6ebfbd97b8e82cf6aaa24211-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .uf3f833ba6ebfbd97b8e82cf6aaa24211:after { content: ""; display: block; clear: both; } READ: Compare the ways Wilkie Collins, Edgar Allen Poe and Roal Dahl create the characters of the villans and the atmosphere of suspense EssayHowever the longer the Time Traveller is in the future he realises that there is another race besides the Eloi. He notices that around the Elois settlement are lots of wells and he hears the puzzling sound of machinery from underground during the night. One morning he catches a glimpse of a like creature he describes as A queer little ape figure but it quickly disappears down one of the wells. He begins to understand that the wells lead down to the underground settlement of the strange white creatures, which seem to be mainly nocturnal. Th e underground creatures are called the Morlocks. He develops another theory in which the Morlocks are the labourers for the Eloi. He thinks about the way his own society in Victorian London has a huge gulf between the rich and the poor. He wonders how significantly the gap may have widened since then. He realised there are now two races of man, The truth dawned on me: that man had not remained one species, but had differentiated into two distinct animals. He contemplated the way that the Morlocks have evolved and adapted to living underground, he believes that they have lived there for many generations, they have developed the features of nocturnal animals, such as large eyes. He ponders the working conditions of some of the railways workers in Victorian London and thinks that even in his time the workers had begun working in such unnatural conditions. He describes the work of an east end worker from Victorian London as working in such artificial conditions as practically being cut off from the natural surface of the world. This is the Time Travellers second revelation. HG Wells has now told us of the way the society is really working, this is a now a criticism of capitalism whereas the reader was originally lead to believe Wells is criticising communism. It seemed clear as daylight to me that the gradual widening of the present merely temporary and social difference between the Capitalist and the Labourer, was the key to the whole position. Wells is saying that the way to avoid the splitting of the human race is to narrow the gap between the fat cats and the workers. Clearly Wells thinks that the common man in Victorian London is not getting a fair deal. He is using the novel to portray this view and, by the use of the story, explaining that if the problem is not addressed then the worker will become another species to the fat cat. In chapter six the Time Traveller decides to go down into a well to attempt to retrieve his Time Machine, which he suspects the Morlocks have stolen. When he returns from the Morlocks subterranean dwelling he has a third theory that he believes is correct. He flatly states that his second theory is wrong. He talks of the way in which the relationship between the Eloi and Morlocks has changed over the generations, The Upper-world people might have been the favoured aristocracy, and the Morlocks their mechanical servants; but that had long since passed away. He now believes that although it appears the Eloi are ruling the future society it is a different story, the Morlocks are really controlling things. The reason that the Morlock still do work for the Eloi he says is as a man enjoys killing an animal in sport: because ancient and necessities had impressed it on the organism. This tells us that the Time Travellers third theory, suggests that the only reason that the Morlocks still live underground and work for the Eloi is because it is the way of life they are customer to. The Time Traveller goes on to explain that the original aristocracy had mistreated the workers in the passed and now the workers were returning to make amends, Thousands of generations ago, man had thrust his brother man out of the ease and sunshine. And now that brother was coming back changed! .ua1a879f31df0eea78f22efe42f8664ea , .ua1a879f31df0eea78f22efe42f8664ea .postImageUrl , .ua1a879f31df0eea78f22efe42f8664ea .centered-text-area { min-height: 80px; position: relative; } .ua1a879f31df0eea78f22efe42f8664ea , .ua1a879f31df0eea78f22efe42f8664ea:hover , .ua1a879f31df0eea78f22efe42f8664ea:visited , .ua1a879f31df0eea78f22efe42f8664ea:active { border:0!important; } .ua1a879f31df0eea78f22efe42f8664ea .clearfix:after { content: ""; display: table; clear: both; } .ua1a879f31df0eea78f22efe42f8664ea { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .ua1a879f31df0eea78f22efe42f8664ea:active , .ua1a879f31df0eea78f22efe42f8664ea:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .ua1a879f31df0eea78f22efe42f8664ea .centered-text-area { width: 100%; position: relative ; } .ua1a879f31df0eea78f22efe42f8664ea .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .ua1a879f31df0eea78f22efe42f8664ea .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .ua1a879f31df0eea78f22efe42f8664ea .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .ua1a879f31df0eea78f22efe42f8664ea:hover .ctaButton { background-color: #34495E!important; } .ua1a879f31df0eea78f22efe42f8664ea .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .ua1a879f31df0eea78f22efe42f8664ea .ua1a879f31df0eea78f22efe42f8664ea-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .ua1a879f31df0eea78f22efe42f8664ea:after { content: ""; display: block; clear: both; } READ: How has globalization changed society EssayIt is not long before the Time Traveller finalises his theories explaining the society. In his fourth he tells us why the Morlocks really are in charge of the society. The Eloi are mere fatted cattle which the ant like Morlocks preserve and pray upon. He has seen that it is the Morlocks pray upon the Eloi and that is the reason that they are feared. HG Wells has used the relationship between Eloi and Morlocks to portray the way he feels his society is going wrong. Fortunately, in hindsight we are able to see that Victorian society did not go to the extreme of splitting the human race into two species. However, there is still a struggle in the world between workers and Capitalists. It would be very easy for HG Wells to argue that the process of dividing the human race is still in progress when there are so many people around the world living and working in conditions not dissimilar to that which transformed humans into Morlocks.

Friday, March 20, 2020

What They Are and How They Were Formed

What They Are and How They Were Formed The word pluvial is Latin for the word rain; therefore, a pluvial lake is often thought of as a formerly large lake created by excessive rain paired with little evaporation. In geography though, the presence of an ancient pluvial lake or its remnants represents a period when the worlds climate was much different from present-day conditions. Historically, such shifts changed arid areas into places with extremely wet conditions. There are also present-day pluvial lakes that show the importance of various weather patterns to a location. In addition to being referred to as pluvial lakes, ancient lakes associated with former wet periods are sometimes put into the category of paleolakes. Formation of Pluvial Lakes The study of pluvial lakes today is mostly tied to that of ice ages and glaciation as the ancient lakes have left distinct landform features. The most prominent and well studied of these lakes are usually related to the last glacial period as this is when they are thought to have formed. Most of these lakes formed in arid locations where there was initially not enough rain and mountain snow to establish a drainage system with rivers and lakes. As the climate then cooled with the onset of climate change, these dry locations turned wet because of different air flows caused by the large continental ice sheets and their weather patterns. With more precipitation, stream runoff increased and began to fill the basins in the formerly dry areas. Over time, as more water became available with the increased moisture, the lakes enlarged and spread across places with lower elevations creating enormous pluvial lakes. Shrinking of Pluvial Lakes Just as pluvial lakes are created by climate fluctuations, they are also destroyed by them over time. For example, as the Holocene epoch began after the last glaciation temperatures around the world rose. As a result, the continental ice sheets melted, again causing a shift in world weather patterns and making the newly wet areas once again arid. This period of little precipitation caused the pluvial lakes to experience a drop in their water levels. Such lakes are usually endorheic, meaning they are a closed drainage basin that retains precipitation and its runoff but it does not have a drainage outlet. Therefore without a sophisticated drainage system and no incoming water, the lakes began to gradually evaporate in the dry, warm conditions usually found in their locations. Â   Some of Today’s Pluvial Lakes Though the most famous of todays pluvial lakes are significantly smaller than they used to be because of the lack of precipitation, their remnants are important aspects of many landscapes around the world. The United States Great Basin area is famous for having the remains of two large pluvial lakes Lakes Bonneville and Lahontan. Lake Bonneville (map of former Lake Bonneville) once covered nearly all of Utah as well as portions of Idaho and Nevada. It formed about 32,000 years ago and lasted until approximately 16,800 years ago. Lake Bonnevilles demise came with reduced precipitation and evaporation, but most of its water was lost as it overflowed through Red Rock Pass in Idaho after the Bear River was diverted to Lake Bonneville following lava flows in the area. However, as time passed and little rain fell into what remained of the lake, it continued to shrink. The Great Salt Lake and the Bonneville Salt Flats are the largest remaining portions of Lake Bonneville today. Lake Lahontan (map of former Lake Lahontan) is a pluvial lake that covered nearly all of northwestern Nevada as well as parts of northeastern California and southern Oregon. At its peak about 12,700 years ago, it covered approximately 8,500 square miles (22,000 square kilometers). Like Lake Bonneville, Lake Lahontans waters gradually began to evaporate resulting in a drop in lake level over time. Today, the only remaining lakes are Pyramid Lake and Walker Lake, both of which are located in Nevada. The rest of the lake’s remnants consist of dry playas and rock formations where the ancient shoreline was. In addition to these ancient pluvial lakes, several lakes still exist around the world today and are dependent on an areas precipitation patterns. Lake Eyre in South Australia is one. During the dry season portions of the Eyre Basin are dry playas but when the rainy season begins the nearby rivers flow to the basin, increasing the lake’s size and depth. This is dependent though on the seasonal fluctuations of the monsoon and some years the lake can be much larger and deeper than others. Todays pluvial lakes represent the importance of precipitation patterns and the availability of water for a locale; whereas the remains of ancient lakes show how a shift in such patterns can alter an area. Regardless of whether or not a pluvial lake is ancient or still existing today though, they are important components of an area’s landscape and will remain so as long as they continue to form and later disappear.

Wednesday, March 4, 2020

Precambrian - The Timeline of Biological History

Precambrian - The Timeline of Biological History The Precambrian (4500 to 543 million years ago) is a vast period of time, nearly 4,000 million years long, that began with the formation of the Earth and culminated with the Cambrian Explosion. The Precambrian accounts for seven-eighths of our planets history. Numerous important milestones in the development of our planet and the evolution of life occurred during the Precambrian. The first life arose during the Precambrian. The tectonic plates formed and began shifting across the surface of the Earth. Eukaryotic cells evolved and the oxygen these eary organisms exhaled collected in the atmosphere. The Precambrian drew to a close just as the first multicellular organisms evolved. For the most part, considering the immense length of time encompassed by the Precambrian, the fossil record is sparse for that time period. The oldest evidence of life is encased in rocks from islands off of western Greenland. Theses fossils are 3.8 billion years old. Bacteria that is more than 3.46 billion years old was discovered in Western Australia. Stromatolite fossils have been discovered that date back 2,700 million years. The most detailed fossils from the Precambrian are known as the Ediacara biota, an assortment of tubular and frond-shaped creatures that lived between 635 and 543 million years ago. The Ediacara fossils represent the earliest known evidence of multicellular life and most of these ancient organisms appear to have vanished at the end of the Precambrian. Although the term Precambrian is somewhat outdated, it is still widely used. Modern terminology disposes of the term Precambrian and instead divides the time before the Cambrian Period into three units, the Hadean (4,500 - 3,800 million years ago), the Archean (3,800 - 2,500 million years ago), and the Proterozoic (2,500 - 543 million years ago).

Monday, February 17, 2020

Ethical Issues in Healthcare Essay Example | Topics and Well Written Essays - 1750 words

Ethical Issues in Healthcare - Essay Example This essay examines some of the key ethical issues concerning contentious health services such as abortion, euthanasia and consent. In brief, the main body contains first paragraphs presenting the arguments in support of the hypothesis and the second against argument on the hypothesis. Our main hypothesis involves the argument for or against the contentious health issues such as abortion, consent or euthanasia. In the process, the essayist looks into the factors involved, the guidance for dealing with specified ethical issue, evaluation of euthanasia based on different moral and ethical arguments. Euthanasia refers to an instance where patients who have a terminal illnesses, such as cancer, HIV/AIDs or diabetes, may opt to propose be given some drugs for terminating life. A nurse or any medical practitioner usually facilitates this. First, it has been argued that people have a right to decide when they want to die and therefore nobody should prevent them from using euthanasia. Secondly, it was revealed that to deny people the right to live their lives as they wish implies that each individual does not know what his or her own rights is. This was based on the concept of individualism, a fundamental factor within a democratic based political theory. The theory reveals that individuals should be given rights to own their life and nobody should question them on how they are managing personal life just like assets. Another argument was that it is wrong to keep any person alive for longer period than they are meant to be.

Monday, February 3, 2020

Critical appraisal of the business plan Essay Example | Topics and Well Written Essays - 750 words

Critical appraisal of the business plan - Essay Example (Shane, 2003) Though I have a wide idea of the business market as far as importing and selling textile goods is concerned but I still have issues in grasping the finer details in this market. For example, I still have a hard time in distinguishing fabrics from South East Asian countries such as from Pakistan, India, Sri Lanka and Bangladesh. This may cause me to buy more expensive fabrics. The other key strength is my ability to regulate finances that I have sizable experience in by managing the finances for myself, my household and my uncle’s business at times. (Reynolds, 2007) I have a hard time grasping custom’s rules because I have paid little attention to them as yet but I would be able to deal with them given thorough study. My experience in working with foreign teams is also limited and I would have to sharpen up my cross cultural communication skills in order to make the business effort work. My business would be provided an opportunity to develop in limited com petition as the market is rebounding although the recovery is slow and may take another half a decade to become viable. I am targeting a market niche where market competition may not be as stiff either as I am not entering the mainstream market but a segregated portion of the textile market. (Ebbena & Johnson, 2006) However, my business venture is in dire threat due to shipping delays for any given reason. My study of the supply and demand in these products tells me that internal disturbances in the producing countries cause delayed shipments although this is not very frequent. However, every delayed shipment means that my rate of return on the investment would suffer considerably. The business sector also suffers from slowed consumer spending as mentioned earlier and this issue serves as a retardant while promoting opportunity too. (Duening et al., 2009) Most of these factors are derived from entrepreneurial traits I have developed over time as well as from a thorough study of the subject market. The targeted audience are middle income groups who are learning to increase their spending capabilities following the recent global economic crunch. This is augmented by the fact that the market was derided of small investors. Since this business model is moving into the space that the small investors left behind so there is a good chance for its workability. (Livingston, 2007) Hence, it is highly reasonable to expect that this business will grow into its niche and will garner the right kind of consumer base. Moreover, the resources needed to make this business model work are all SMART (specific, measurable, attainable and time bound). This ensures that the business is built on concrete ideas and on as little speculation as possible. (Entrerprise UK, 2011) I have a primary contact within the South East Asian manufacturing belt who is capable of getting goods manufactured to specification and shipped accordingly. Moreover, a storage area near the main display shop can easily be arranged given that such storage areas exist near markets and malls. A display area would be required to sell the product and such a retail area can well easily be located in a central shopping district. It would pay to have the business in as competitive and large a shopping district as possible but that would cost too much money for a business that is already dealing with decent finance levels. Most businesses fail in the longer run for want of finance and hiring a place that costs too much in terms of rent will more or less push the business into a state of insecurity in terms of finance. Moreover, it would be unreasonable to expe

Sunday, January 26, 2020

Lesch-Nyhan Syndrome: Physiology and Features

Lesch-Nyhan Syndrome: Physiology and Features Discuss the inheritance, molecular and biochemical defects underlying the clinical features associated with Lesch-Nyhan syndrome. The Lesch-Nyhan syndrome is a rare heritable disorder of inborn error metabolism of purine which was examined in 1964 by Lesch and Nyhan. They investigated the two brothers with hyperuricemia and neurobehavioral problems and suggested that this disorder involves motor impairment and self-injurious behaviors (Lesch, M and Nyhan, W. L., 1964). The popularity of Lesch-Nyhan syndrome is about 1 in 380000 individuals and this disorder presents solely in male. (Seegmiller, J. E., et al, 1967). It is passed on since the X-linked recessive trait causes genetic mutation followed by the exertion of an enzyme called hypoxanthine guanine phosphoribosyltransferase (HGPRT). In the metabolic condition, Lesch-Nyhan syndrome is recognized by purine overproduction (Nyhan, W. L, et al, 1967) which contributes to increased level of uric acid significantly. The clinical features associate with Lesch-Nyhan syndrome are briefly outlined and the inheritance, molecular and biochemical defects underlying the clinical features are also discussed. Figure 1. The clinical features associated with Lesch-Nyhan syndrome. This disorder leads to neurobehavioral syndrome involving motor dysfunction, cognitive impairment and self-injurious behaviors (Mumues, 2015).    The clinical characteristics of Lesch-Nyhan syndrome are defined by motor defection leading to neurological operation, cognitive and behavioral impairment, and also overproduction of uric acid or hyperuricemia (van der Zee et al., 1968). Moreover, neurological disturbance is majorly performed as hypotonia and developmental delay which are obviously expressed by three to six months. The children are interrupted in sitting and walking or require a wheelchair in severe condition. Additionally, the twitch of facial muscles and limbs can be observed in elder children. During the first ages, the extrapyramidal difficulties such as dystonia and choreoathetosis or the pyramidal difficulties like spasticity and hyperreflexia become noticeable (Jinnah and Friedmann, 2001). Furthermore, cognitive dysfunction and behavioral impairment occurring between two to three years old can lead to moderate or serious mental hindrance. Also, the continuous self-injurious behaviors such as biting the fingers or lips and hitting the head or limbs are the most distinctive behavioral symptom in patients (Nyhan, W. L, et al, 1968). Lesch-Nyhan syndrome is also characterized by overproduction of uric acid and this induces the decomposition of uric acid crystals in kidneys, ureters or bladder and the gouty arthritis can be developed later in the disorder (Page et al, 1987). Figure 2. The inheritance detects of Lesch- Nyhan syndrome. This X-linked recessive syndrome is solely for the male and the chance taken from the sons and daughters with either affected father and unaffected mother or unaffected father and carrier mother are showed (IFFA, 2016). Firstly, the Lesch- Nyhan syndrome is inherited in an X-linked recessive characteristic since the mutation of HPRT gene is positioned on the X chromosome and this disorder is described to the male only (Hoefnagel et al, 1965). More importantly, the X-linked inheritance determined that the X-linked character cannot be transferred from the father to the son. In this syndrome, the Lyon hypothesis can be adopted to demonstrate the mothers are heterozygous and the mosaics involve two cell cultures where one is entirely normal and another one is fully faulty (Migeon et al, 1968) . An investigation is examined that the fibroblasts developing in the cell populations from the skin were duplicated (Migeon, B. R, et al, 1968) and HGPRT deficiency in the negative duplication can be observed through radioautographical method. Furthermore, the halt of the X chromosome is not described as a random activity because HGPRT in the erythrocytes or leukocytes of obliged heterozygotes for this situation i s distinct with the glucose 6-phosphate dehydrogenase (G6PD) deficiency where the transportation of enzyme in heterozygotes is around 50%. It is indicated that the enzyme action in the erythrocytes of the mothers with Lesch-Nyhan syndrome are normal. Also, the blood-relative family in two kinds of G6PD and HGPRT (Nyhan, W. L.et al, 1970) are separating so this shows that females were heterozygous to G6PD. The reason why the males have more frequent chance to suffer from this X linked recessive syndrome than the females is because the males contain only one X chromosome and one changed copy of the gene is enough to lead to this syndrome and it is uncommon that females possess two changed copies of the gene Vogel (1977). It is examined that the father of a male patient is not the carrier of the mutated gene and also do not suffer from the syndrome. The chance taken from the siblings rely upon the carrier condition of the mother. Carrier women contain a 50% chance of passing on the HPRT1 variation in each gestation. The sons who receive that variation will be influenced and the daughters who obtain the variation are served as carriers. Hence, it can be concluded that a carrier mother has a one-fourth chance of getting an affected son, one-fourth chance of getting a carrier daughter and half chance of getting a normal son or daughter (Genetic Home Reference, 2007). Figure 3. Purine metabolism with de novo synthesis and salvage synthesis. The de novo purine synthesis is mobilized by the enzyme, PRPP amidotransferase, and the salvage pathway by hypoxanthine phosphorybosyltransferase (HPRT) and adenine phosphorybosyltransferase (APRT). HPRT catalyzes the salvage synthesis of inosine monophosphate, IMP, and guanosine monophosphate, GMP, from hypoxanthine and guanine particularly by using PRPP as a co-substrate. The HPRT deficiency leads to decomposition of hypoxanthine and guanine which are transformed into uric acid by xanthine oxidase. Purine overproduction, increase level of PRPP and decrease level of IMP and GMP are the results (Torres R J and Puig J G, 2007). Secondly, Lesch-Nyhan syndrome contributes to the molecular defects due to the mutation of HPRT1 gene which encrypts hypoxanthine phosphoribosyltransferase. This enzyme is used to recycle purines and is responsible for transferring hypoxanthine and guanine back into DNA synthesis which establish the cells to possess enough supply of building blocks and assemble DNA and RNA (Sweetman, L and Nyhan, W. L. 1972). The deficiency of HPRT map to chromosome Xq26-q27.2 and is likely to cause heterogenous mutations (Greene, M. L, et al, 1970). Also, it induces the increased level of purine nucleotides by purine salvage pathway. It leads to decomposition of uric acid because of the broken down but unrecycled purines and occurrence of excessive PRPP, resulting in the neurological and behavioral problems of Lesch-Nyhan syndrome (Kelley, W. N, 1968). The de novo pathway is initiated with the active form of ribose from ribose-5-phosphate to 5-phosphoribosyl-1-pyrophosphate (PRPP) and this synthesis discharges AMP. PRPP gives rise to the first nucleotide called inosine monophosphate (IMP) by an enzyme PRPP amidotransferase which serves as the rate-limiting step. Besides, IMP uses as a forerunner of AMP and GMP synthesis and the route of pathway is modulated by the higher level of particular nucleotide (Fox, I. H and Kelley, W. N, 1971). There are two main transferase enzymes involving in the purines salvage pathway. HPRT is responsible for catalyzing the hypoxanthine to inosine monophosphate (IMP) and guanine to guanosine monophosphate (GMP) and another one is adenosine phosphoribosyltransferase (APRT) which assembles adenine to AMP through transferring the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate (PRPP) (Keebaugh et al., 2007). The AMP, GMP, IMP are all catabolized to uric acid and particular mononucleotides is started with the transformation to the phosphate free nucleoside via cytosolic 5-nucleotidases. After that, the nitrogen is eliminated from adenosine to produce inosine with an enzyme, adenosine deaminase (ADA). The ribose is discarded from the nucleotides by purine nucleoside phosphorylase (PNP) and create hypoxanthine, xanthine and guanine (Rubin, C. S.et al, 1969). The nitrogen is then eliminated from guanine through guanine deaminase and xanthine is produced. Eventually, hypoxanthine and xanthine are converted to the final product of purine catabolism called uric acid by xanthine oxidase (Kelley, W. N, et al, 1970). It can be concluded that HGPRT deficiency leads to higher level of PRPP because of its rate limiting function and decreased level of GMP and IMP, resulting in increased de novo purine synthesis and degradation of purines to contribute to the higher level of uric acid called hyperuricemia and cause Lesch-Nyhan syndrome (Rosenbloom, F. M, et al, 1968). Thirdly, the biochemical defects can be determined by the purine metabolism of the Lesch-Nyhan syndrome and the metabolism can indicate the rate of uric acid synthesizing from 14C-labeled glycine (Sweetman, L. 1968). Also, the deficiency of HPRT contributes to the excessive purine synthesis and this enzyme acts as a regulating role in purine metabolism. The specific activity of the uric acid can be examined by the isolation and purification from urine. In the children with Lesch-Nyhan syndrome it is observed that accelerated specific activity in the uric acid obtain 20 times higher glycine concentration salvaged in uric acid than the control individuals (Nyhan, W. L.et al, 1968). Thus, it leads to the higher level of purine overproduction in patients. Besides, the rate of de novo synthesis of purine using fibroblasts grown in cell culture can be demonstrated (Seegmiller, J. E., et al, 1967). There is a significant relationship between asperity of disorder and recycle of hypoxanthine or guanine. The expressions of intracellular purines are normal within the fibroblasts with deficient HGPRT but purine depletion is apparent since the increased purine metabolites are discharged from cells. In addition, the normal purines were probable to cause a compensative increase in purine synthesis due to notable rising in purinosomes. Moreover, the purine de novo overproduction showing in this syndrome is an unsuccessful feedback regulation. The first step of the purine pathway is catalyzed by phosphoribosyl pyrophosphate amidotmnsfemse and is dependent to feedback inhibition by adenine and guanine. 2-ethylamino-l,3,4-thiadiazole was used for the examination and the observation showed that uricogenic agent significantly increases the rate of purine synthesis in normal conditions but in the patients the rates of purine synthesis increase more intensely by this agent (Nyhan, W. L.et al, 1968). Furthermore, the existence of xanthinuria in patients with inborn deficiency of xanthine oxidase expresses the abnormalities in the central nervous system. In the cerebrospinal fluid (Sweetman, L. 1968) the xanthine levels are equivalent to the controls and the hypoxanthine level in patients with the Lesch-Nyhan syndrome were greater than the controls by four times. Hence, Hypoxanthine and guanine recycling and the de novo pur ine synthesis are demonstrated to determine the biochemical abnormality of Lesch-Nyhan syndrome. In conclusion, by the discussion of the inheritance, molecular and biochemical defects that determining the clinical trait correlated with the Lesch-Nyhan syndrome, it is demonstrated that this X-linked recessive disorder is exclusive for males and is induced from the mutation of HGPRT gene which contributes to the overproduction of uric acid by purine salvage pathway and causes neurobehavioral problems of affected individuals (Rosenbloom, F. M.et al, 1968). For the future perspectives, although there is no treatment to cure this disorder, effective medications can be adopted to alleviate the symptoms such as managing the uric acid levels by allopurinol and reducing behavioral problems by taking diazepam or haloperidol appropriately (Genetics Home Reference, 2007). (Word count: 1639) References: Fox, I. H and Kelley, W. N. 1971. Ann. Intern. Med. 74:424-33  Genetics Home Reference, 2007. Lesch-Nyhan syndrome. Retrieved on 24/5/2007. Greene, M. L and Boyle, J. A, 1970. Science 167:887- 89 Hoefnagel, D, et al, 1965. Hereditary choreoathetosis, self-mutilation and hyperuricemia in young males. New Eng. J. Med. 273: 130-135, 1965. IFFA, 2016. Lesch-Nyhan Syndrome on emaze. [digital image] Retrieved from: https://www.emaze.com/@ACFTIZWL/Lesch-Nyhan-Syndrome Jinnah, H. A and Friedmann, T. 2001. Lesch-Nyhan disease and its variants.In: Scriver, C. R.; Beaudet, A. L.; Sly, W. S.; Valle, D. (eds.): The Metabolic Molecular Bases of Inherited Disease. Vol. II. (8th ed.) New York: McGraw-Hill (pub.) P. 2537. Kelley, W. N, 1968. Fed. Proc. 27: 1047-52 Keebaugh, A. C and Sullivan, R. T, 2007. NISC Comparative Sequencing Program, Thomas, J. W. Gene duplication and inactivation in the HPRT gene family. Genomics 89: 134-142. Kelley, W. N, et al, 1970. Biochim. Biophys. Acta 21 5 :512-16 Lesch, M and Nyhan, W. L, 1964. Am. J. Med. 36:561-70 Mumues, 2015. Mental retardation. [digital image] Retrieved from: https://www.slideshare.net/mumues/mental-retardation-44326087 Migeon, B. R, et al, 1968. X-linked hypoxanthine-guanine phosphoribosyl transferase deficiency: heterozygote has two clonal populations. Science 160: 425-427. Nyhan, W. L, 1967. Pediat. 67 :257-63 Nyhan, W. L, et al, 1968. Metabolism 17 :846-53 Nyhan, W. L, et al, 1970. Proc. Nat. Acad. Sci. USA 65:214-18 Page, T, et al, 1987. Syndrome of mild mental retardation, spastic gait, and skeletal malformations in a family with partial deficiency of hypoxanthine-guanine phosphoribosyltransferase. Pediatrics 79: 713-717 Rubin, C. S, et al, 1969. J. Lab. Cfin. Med. 74:732-41 Rosenbloom, F. M, et al, 1968. Bioi. Chern. 243 : 1 166-73 Seegmiller, J. E, et al, 1967. Science 155: 1 682-84 Sweetman, L. 1968. Fed. Proc. 27 : 1 055-59 Sweetman, L and Nyhan, W. L. 1972. Arch. Intern. Med. 130:214-20 Torres R J and Puig J G, 2007. Hypoxanthaine-guanine phosphoribosyltransferase (HPRT) deficiency: Lesch- Nyhan Syndrome. Orphanet J Rare Dis. 2, 1. [digital image] Retrieved from: https://en.wikipedia.org/wiki/Lesch%E2%80%93Nyhan_syndrome#/media/File:HPRT_metabolism.jpg Vogel, F, 1977. A probable sex difference in some mutation rates. (Editorial) Am. J. Hum. Genet. 29: 312-319.   Ã‚  

Friday, January 17, 2020

Language & Human Communication

Of all human skills, language is one of the most valuable because it allows us to communicate with one another. Human communication is important to society, enabling business and interpersonal relationships, as well as teaching and learning. Language is also important because it allows people to create new words for a changing society, like â€Å"Internet,† according to Palomar College. About Language 1. Languages are, essentially, systems of symbols that have meaning. Language is a means of human communication, whether it be expressed verbally, it writing or through sign language. All languages have a system of rules and meanings and can express an infinite number of ideas or meanings within that system. Human Language Development 2. Language is a part of human development, beginning its development in early childhood. Human language begins with what is called â€Å"babbling,† when infants make repetitive sounds like â€Å"mah mah† and â€Å"dah dah† that mark the beginning of speech development. Language is an important part of intellectual development and the development of communication skills. Communication, in turn, is vital to human language development. According to Palomar College, studies show that parents can help infants develop language skills by communicating with them often using and encouraging appropriate language rules. As the child's language skills continue to develop, he may begin to use language, albeit incorrectly. Gently correcting the child's speech can help her improve. If a child says, â€Å"I seen it,† for instance, correct by saying something like, â€Å"Yes, that's good, you saw it. I saw it, too,† thus illustrating the appropriate form of the verb â€Å"to see. † Communication and Language 3. Even though language is standardized, the interpreted meaning of the words that being communicated is influenced by a variety of factors about the situation. The way something is phrased, the tone in which it is said and the volume all matter. These â€Å"hidden† parts of communication affect way the listener interprets the speaker, according to Palomar College. Other Parts of Language 4. The message delivered through language may also be mediated by nonverbal or non-linguistic factors like body language and gestures. According to Palomar College, linguists and other language experts refer to nonverbal elements of language like tone of voice, smiling, frowning, use of personal space and other unspoken means of communication as â€Å"paralanguage† elements. Paralanguage can be just as important to human communication as language itself. In-Person Communication 5. While words are powerful, the power of in-person communication cannot be overlooked. According to Palomar College, it is estimated by researchers that up to 70 percent of the meaning derived from in-person communication comes from paralinguistic expressions. This is because paralanguage communicates the emotional and personal aspects of human communication that can be unseen in written and impersonal forms of language use.

Thursday, January 9, 2020

Essay about Allegory and Satire in The Lottery, by Shirley...

Originally printed in the June 26, 1948 issue of The New Yorker, Shirley Jackson’s â€Å"The Lottery† brought about controversy from the beginning. Magazine subscriptions were immediately canceled due to the outrage at the brutal underlying message. Mrs. Jackson tore down virtually every institution that American Citizens hold dear to their hearts. Jackson believes we should not just blindly follow authority or blindly partake in any traditions that we may not understand to the full extent. â€Å"Any human institution which is allowed to continue unchallenged and unconsidered until it becomes a destructive, rather than a constructive, force in mens lives†¦Ã¢â‚¬  â€Å"The Lottery† explicates this in a manner in which you must know the underlying message to†¦show more content†¦This all symbolizes Christianity upholding the traditions that we blindly follow unquestioningly. In â€Å"The Lottery† the tradition that the citizens blindly follow is one of collective violence, therefore Jackson, in a roundabout manner, ties Christianity not only to the blindly held traditions, she also hints that The Christian Faith has led people to do cruel violent things, aligning Christianity with evil. Jackson attempts to show that no matter what you claim to be if your acts are contrary to the beliefs you claim to up hold, your innermost goals will be seen. Nazi Germany claimed to be Christian, yet they committed terrible crimes and horrific acts of murder. Some critics believe that Jackson wrote to allegorize this; she alluded to it yes, as an example but not as a main subject. Jackson further ties her story to Christianity through the use of stones as the murder weapons. Stoning first appeared in Biblical Days. Christians are not the only culprits that used this method of execution though, â€Å"stoning comes up specifically in the religious texts of all three of the Abrahamic religions: Christianity, Judaism, and Islam.†(Shm oop Editorial Team) This method of execution is one of collective violence it is not limited to one or two executioners, in â€Å"The Lottery† the entire town joins in on the violence, even the children participate. This inclusion of every person teaches the children asShow MoreRelatedEssay about The Lottery, by Shirley Jackson2214 Words   |  9 PagesWorld War, Shirley Jackson’s life was filled with graphic imagery of the violence existing throughout her world. Jackson’s husband Stanley Edgar Hyman wrote, â€Å"[Shirley’s] fierce visions of dissociations and madness, of alienation and withdrawal, of cruelty and terror, have been taken to be personal, even neurotic fantasies. Quite the reverse: They are a sensitive and faithful anatomy of our times, fitting symbols for our distressing world of the concentration camp and the bomb† (â€Å"‘The Lottery’† 144)Read MoreThe Lottery, by Shirley Jackson Essay example2088 Words   |   9 Pagesimagery of the violence existing throughout her world filled the life of Shirley Jackson. Jackson’s husband Stanley Edgar Hyman wrote, â€Å"[Shirley’s] fierce visions of dissociations and madness, of alienation and withdrawal, of cruelty and terror, have been taken to be personal, even neurotic fantasies. After two rounds of drawing, one to choose the family, and one to choose the member of that family, Tessie Hutchinson â€Å"wins† the lottery. She is then stoned to death by the rest of the people of the townRead MoreEssay about The Life and Literary Works of Shirley Jackson4264 Words   |  18 PagesShirley Jackson was born on December 14, 1919 to Leslie and Geraldine Jackson. Her surroundings were comfortable and friendly. Two years after Shirley was born, her family with her newborn brother moved from San Francisco to Burlingame, California, about thirty miles away. According to her mother, Shirley began to compose verse almost as soon as s he could write it (Friedman, 18). As a child, Shirley was interested in sports and literature. In 1930, a year before she attended Burlingame High SchoolRead MoreUtopia and Dystopia in Harrison Bergeron and The Lottery Essay examples1345 Words   |  6 Pagesexploits into an exaggerated worst-case scenario. The short stories, Harrison Bergeron, and The Lottery, are both literary examples imparted around a utopian society. Harrison Bergeron, was written by Kurt Vonnegut in 1961. This story elucidates a dystopian society that is derived of its individuality and is expected to conform to authorities. The Lottery, is a short story written by Shirley Jackson that was published in June, 1948 and exerts a story that an impelling outlook on a seamlessly

Wednesday, January 1, 2020

Sample of a Formal Business Report

Sample of a Formal Business Report Sample Formal Business Report Purpose: The purpose of this document is to present a 5-year operational plan for the container leasing of company ABC. The document is aimed at highlighting the main objectives and the vision of the company. Another aim is to develop a thorough action plan for operational aspects of the business. The target of this business plan is to align the company’s growth ambitions with the operational and financial limitations it faces. In order to achieve growth and to make sure that commercial objectives are backed up from the operational perspective, scenario analysis of the estimated container availability was undertaken. Our findings: The company’s annual growth is estimated at 10.1% which would mean an increase of 1.3 million units by the end of 2015 in TEU terms. Major growth is expected to come from trading with China. Significant drop in the availability of refrigerated equipment is a major challenge. With the estimated drop of 12%, this issue should be addressed immediately. Recommendations: We recommend the following action plan based on the major points outlined. To increase the investment rate to 2.3 million dollars. To diversify the risks.